Category: Pop. Genetics

Summary: Finding how much directional asymmetry in dormant-to-active reactivation is needed to depin a modular localized quasispecies mode while the population remains persistent.

Quasispecies models ask how mutation, selection, and landscape structure shape where a population concentrates in sequence space. This experiment studies a modular landscape with a seed bank and asks when asymmetric reactivation from dormancy is strong enough to pull the dominant mode out of a module-localized state without destroying persistence altogether.

The model builds a dense active-plus-dormant operator and increases system size through iterative deepening while bisecting the reactivation-asymmetry parameter. That turns the problem into a finite-size threshold search for the point where modular localization breaks down under combined mutation, recombination, and seed-bank buffering.

The novelty is not the individual ingredients, all of which are known separately, but their combination in one dense threshold map. The result is meant to quantify a directional reactivation effect that is usually discussed qualitatively rather than pinned down as a finite threshold.

Method: Dense non-symmetric eigensolve with iterative deepening and bisection on dormant-to-active reactivation asymmetry in a 2N x 2N quasispecies operator.

What is measured: Critical reactivation-asymmetry threshold, localization or depinning of the leading mode, persistence status, and threshold bracket width.